Zhao Lab

Selected publications:

Zhao X, Yan X, Contrepois K, Vallania F, Ellenberge M, Kashiwagi CM, Gagnon SD, Siebrand CJ, Cabruja M, Traber GM, McKay A, Hornburg D, Khatri P, Snyder MP, Zare RN, Brunet A. Lipidomic profiling reveals age-dependent changes in complex plasma membrane lipids that regulate neural stem cell aging. bioRxiv [Preprint]. 2022 August 19. Available from: https://www.biorxiv.org/content/10.1101/2022.08.18.503095v1 DOI: 10.1101/2022.08.18.503095

Yan X*, Zhao X* (equal contribution), Zhou Z*, McKay A, Brunet A, Zare RN. Cell-type-specific metabolic profiling achieved by combining Desorption Electrospray Ionization Mass Spectrometry Imaging and immunofluorescence staining. Anal Chem. 2020 Oct 6;92(19):13281-13289. PubMed Central PMCID: PMC8782277.

Zhao X, Petrashen AP, Sanders JA, Peterson AL, Sedivy JM. SLC1A5 glutamine transporter is a target of MYC and mediates reduced mTORC1 signaling and increased fatty acid oxidation in long-lived Myc hypomorphic mice. Aging Cell. 2019 Jun;18(3):e12947. PubMed Central PMCID: PMC6516164.

Hofmann JW*,Zhao X* (equal contribution), De Cecco M, Peterson AL, Pagliaroli L, Manivannan J, Hubbard GB, Ikeno Y, Zhang Y, Feng B, Li X, Serre T, Qi W, Van Remmen H, Miller RA, Bath KG, de Cabo R, Xu H, Neretti N, Sedivy JM. Reduced expression of MYC increases longevity and enhances healthspan. Cell. 2015 Jan 29;160(3):477-88. PubMed Central PMCID: PMC4624921. Perspective: Carroll PA, Eisenman RN: Growing old with Myc. Cell, 2015, 160(3):365-366.

Other publications

  1. Leeman DS, Hebestreit K, Ruetz T, Webb AE, McKay A, Pollina EA, Dulken BW, Zhao X, Yeo RW, Ho TT, Mahmoudi S, Devarajan K, Passegué E, Rando TA, Frydman J, Brunet A. Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging. Science. 2018 Mar 16;359(6381):1277-1283. PubMed Central PMCID: PMC5915358.
  2. Sedivy JM, Kreiling JA, Neretti N, De Cecco M, Criscione SW, Hofmann JW, Zhao X, Ito T, Peterson AL. Death by transposition – the enemy within?. Bioessays. 2013 Dec;35(12):1035-43. doi: 10.1002/bies.201300097. Epub 2013 Oct 15. PubMed PMID: 24129940; PubMed Central PMCID: PMC3922893.
  3. De Cecco M, Jeyapalan J, Zhao X, Tamamori-Adachi M, Sedivy JM. Nuclear protein accumulation in cellular senescence and organismal aging revealed with a novel single-cell resolution fluorescence microscopy assay. Aging (Albany NY). 2011 Oct;3(10):955-67. doi: 10.18632/aging.100372. PubMed PMID: 22006542; PubMed Central PMCID: PMC3229972.
  4. Sedivy JM, Kreiling JA, Neretti N, De Cecco M, Criscione SW, Hofmann JW, Zhao X, Ito T, Peterson AL. Death by transposition – the enemy within?. Bioessays. 2013 Dec;35(12):1035-43. doi: 10.1002/bies.201300097. Epub 2013 Oct 15. PubMed PMID: 24129940; PubMed Central PMCID: PMC3922893.
  5. Gu W, Ge HM, Song YC, Ding H, Zhu HL, Zhao X, Tan RX. Cytotoxic benzo[j]fluoranthene metabolites from Hypoxylon truncatum IFB-18, an endophyte of Artemisia annua. J Nat Prod. 2007 Jan;70(1):114-7. doi: 10.1021/np0604127. PubMed PMID: 17253861.